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    Your support of DEBRA International or a national EB group enables us to provide the best quality of life for families and individuals affected by EB.

Donation Account: IBAN AT65 6000 0005 1004 5254, BIC BAWAATWW, DEBRA International, Am Heumarkt 27/1, 1030 Vienna

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The Use of Animals in Research

DEBRA has a strict policy regarding the welfare for animals used in research, and funding is awarded only to researchers abiding by the relevant legislation, and in accordance with the '3R' principles.

Whilst keeping the numbers of animals used in EB research to a minimum, some work using animals, mainly mice, is necessary to make progress. Animal models of EB are used both in basic research into understanding the causes of EB and in preclinical research, which is necessary before therapies can be tested on humans in clinical trials.

Regulatory authorities in most countries require researchers to demonstrate the safety and effectiveness of therapies in animal models before approval for clinical trials.

We actively take advice from organisations aiming to reduce animal use and improve the welfare of animals that are used, and we favour the use of non-animal experimental approaches wherever possible, for example, through the use of cultured cells or engineered ‘human skin equivalents’.

DEBRA International grant applications require researchers to demonstrate that the researchers have considered animal welfare and are licensed to carry out the proposed research. We reject research proposals where the welfare of animals is not given due consideration.

DEBRA-funded researchers are required by contract to abide by national legislation and adopt the highest animal welfare standards as well as the '3R' principles:

Replace where possible the use of animals with other lab techniques.
Refine the use of animals to minimise their use and the severity of procedures carried out.
Reduce the number of animals used to the minimum.

DEBRA International endorses the statement on the use of animals in research by the UK Association of Medical Research Charities (AMRC).