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| DebRA
International Current Research Projects |
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Creation of a murine model of squamous cell
carcinoma in epidermolysis bullosa |
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| Name of Researchers: |
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Prof. Ian Hart,
Richard Dimbleby,
Prof. John McGrath,
Dr Kairbaan Hodivala-Dilke. |
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| Places of Research: |
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Department of Cancer Research, Rayne
Institute, St Thomas’ Hospital.
St John’s Institute of Dermatology, St Thomas’
Hospital
ICRF Laboratory, St Thomas’ Hospital. |
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Approved by DebRA
Medical & Scientific Advisory Panel: |
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Budget approved by
DebRA central Committee: |
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| Date Commenced: |
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/02/2002 3 years |
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SUMMARY OF RESEARCH BEING UNDERTAKEN
The advances in the treatment of symptoms of EB have led
to improved quality of life for many people with EB. Unfortunately, many people with
recessive dystrophic EB are at risk from skin cancer although the reasons for this
increased incidence are unknown. Development of new ways to treat this complication of the
disease is needed.
To understand how the cancer develops and to test novel treatments targeted against
this specific tumour, the scientific community needs a model system. This research plans
to develop a mouse model of this specific aspect of EB, using a technique where the
resulting gene is genetically "cut out" in a specific area of the skin, and to
characterise the specific biological characteristics of the cancers arising in this site
of skin blistering.
FINANCIAL SUMMARY
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Year 1 £ |
Year 2 £ |
Year 3 £ |
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| Staff |
31,569 |
34,906 |
38,278 |
| Expenses |
15,500 |
15,500 |
13,400 |
| Management @ 5% |
2,356 |
2,524 |
2,582 |
| TOTAL |
49,425 |
52,930 |
54,260 |
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