Symptoms and outcomes of EB Simplex This section describes the specific features of EB simplex that are, besides the general features, only (or only to that extent) present in EB simplex. EB simplex is generally a relatively mild form of EB. The features are usually confined to external and internal blistering. External blistering Blistering may already manifest itself a few hours after birth; however, in some cases this does not occur until a couple of days or weeks after being born. There are even cases known in which EB-simplex did not manifest itself until adole-scence. As a rule blisters heal within 2 to 10 days. In most forms of EB simplex blistering does not necessarily leave scars but it will often take some time for the red discolo-rations of the wounds to disappear. When the healing process has been completed it is often impossible to detect the earlier location of the blister. However, an infected wound may easily leave scars. In childhood there are often blisters. A new blister may be formed after another one has just healed. Once adolescence has been reached, an improvement often presents itself which usually continues for the remaining part of life. An adult has usually less blistering problems. A tendency for blisters will remain throughout life. Locations that have been chronically wounded and therefore scarred in childhood have a tendency for recurrent blistering at a later age. Internal blistering In the first week after birth sometimes painful blisters and wounds become manifest. In children partial or full disappearance of the epithelium of the tongue may occur. In childhood these features will only be present occasionally. Approximately 2% of all EB simplex patients continue to have these mouth and throat problems. Eye disorder In patients with EB simplex, eye problems are sometimes manifested. In a number of cases reappearing infection of the rim of the eyelids has been reported. |
