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EB2012, Marbella

  • EB research conference

    The triennial DEBRA International research conference took place from 5-7 Nov 2012 in Marbella, Spain.

    A scientific conference report has been published in the Journal of Investigative Dermatology, and a lay summary is available, too.

    For the programme, see the box on the left.

    Find below a list of 
    poster abstracts, the organisation team as well as a gallery of selected pictures of the conference.

Poster abstracts

Following are the titles of scientific posters which were presented at the conference. Click a title to get to the poster abstract of a particular project.

Poster abstracts - List of titles
1Management of pain in severe hereditary epidermolysis bullosa: Experience of a referral centre and implementation of a protocol adapted
2A national reference centre for the clinical management of Hereditary Epidermolysis bullosa: MAGEC
3EBCare, the first patient-reported international online EB patient registry
4Human Cord Blood (CB) Derived Unrestricted Somatic Stem Cells (USSCs) Promote Wound Healing and Have Therapeutic Potential for Patients With Recessive Dystrophic Epidermolysis Bullosa
5Genetic Repair of Epidermolysis Bullosa Point Mutations using induced Pluripotent Stem Cell Technologies
6Gene correction of recessive dystrophic epidermolysis bullosa patient-specific induced pluripotent stem cells
7Differentiation of human induced pluripotent stem cells into dermal fibroblasts
8Unrelated cord blood transplantation with mesenchymal stromal cell co-infusion in patients with severe epidermolysis bullosa. A phase I/II trial in the Netherlands.
9C7 plays a dual role in skin wound healing
10Restoration of Collagen Type VII Expression in Recessive Dystrophic Epidermolysis Bullosa using a Cationic Polymer
11Targeting dominant-negative keratin mutations in EBS keratinocytes
12Radiological findings by Barium Esophagram in mexican patients with dystrophic epidermolysis bullosa
13Measuring Quality of Life in Epidermolysis Bullosa in Mexico: Cross Cultural Validation of the Hispanic Version of the Quality of Life in Epidermolysis Bullosa Questionnaire
14Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity
15Loss of collagen VII increases aggressive tumor behavior in Col7al hypomorphic mice
16Reporter-based pre-evaluation of trans-splicing molecules improves endogenous COL7A1 mRNA repair
17Integrin a3 mutations cause a new disease affecting kidney, lung and skin
18DNA Constructs For Sustained COL7A1 Expression In Recessive Dystrophic Epidermolysis Bullosa Cells
19Non viral gene transfer via Sleeping beauty transposon for Collagen VII delivery in human primary keratinocytes.
20The www.col7.info database for COL7A1 variants (Dystrophic Epidermolysis Bullosa)
21Allogeneic fibroblast cell therapy for recessive dystrophic epidermolysis bullosa
22Confluence switch signaling regulates ECM composition and plasmin proteolytic cascade in keratinocytes
23Dystrophic epidermolysis bullosa with immunofluorescence findings mimicking transient dermolysis of the newborn as presenting feature of recessive DEB with a novel COL7A1 gene mutation
24Molecular Identification of Collagen 17a1 As a Major Genetic Modifier of Epidermolysis Bullosa in Mice
25Revertant mosaicism in Kindler syndrome results from slipped mispairing and mitotic recombination
26Revertant cell therapy for epidermolysis bullosa
27Melanocyte supply to the epidermis in human skin depends on type XVII collagen
28Natural gene therapy occurs in all patients with generalized non-Herlitz junctional epidermolysis bullosa with COL17A1 mutations
29Revertant mosaicism in children with non-Herlitz junctional epidermolysis bullosa
30An International Repository for Mouse Models of Epidermolysis Bullosa
31Topically applied Flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita
32Effect of Flightless I on skin barrier development, function and recovery post skin blistering
33Transplantation of Hair Follicle Dermal Cells as a Therapeutic Approach for Recessive Dystrophic Epidermolysis Bullosa
34Sequence optimization of RNA trans-splicing molecules increases the specificity of toxin induced cell death in a cancer gene therapy approach in vitro
35Double RNA trans-splicing induced gene correction in epidermolysis bullosa
36Functional correction of mutations in murine and human COL7A1 by 5' trans-splicing
37Dermal matrix composition promotes development of aggressive squamous cell carcinoma in recessive dystrophic epidermolysis bullosa
38Polo-like kinase 1 inhibitors hold potential as targeted therapies for recessive dystrophic epidermolysis bullosa associated cutaneous squamous cell carcinoma
39Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna

Organisation team

  • Sincere thanks go to DEBRA Spain for hosting EB2012 and to Dr Clare Robinson, DEBRA International research manager, for masterminding it.

    Please do not hesitate to contact the organisation team if you have any questions or remarks.

  • Organisation team
    Dr Clare Robinsonresearch programme
    Evanina Makowlocal organiser
    Minerva Quijeralocal organiser
    Susan Sableregistration

Picture gallery

(click to enlarge)

  • Conference room: Flamenco performance opening the conference
  • First slide of a PPT-presentation showing "Welcome to EB 2012"
  • Registration desk with members of the DEBRA Spain team (conference host)
  • 2 DEBRA posters with the claim "This is what life feels like to Butterfly Children" in the front; registration desk with volunteers waiting for registrants
  • Researcher at registration desk, and gets his folder
  • Mrs. Nieves Montero, president of DEBRA Spain, (conference host) opening the conference
  • Group picture of (FLTR): Manolo Cardeña (social services council, Marbella town hall), Mrs Nieves Montero, president of DEBRA Spain, Dr Clare Robinson, DEBRA International research manager, Alicia Jimenez (health council, Marbella town hall)
  • Conference chairs Prof Leena Bruckner-Tuderman and Prof Jouni Uitto opening the conference
  • Dr Waseem Qasim and Prof Gim Meneguzzi are chairing session 2 "Gene Correction and Delivery"
  • Prof John McGrath showing a PPT slide with the title of his talk "From fibroblasts to MSC: clinical trials and mechanisms of skin repair in EB"
  • Koen van Rossem of GSK speaks about "Industry perspective on EB therapy"; the PPT slide shows a  four-leaf clover; written on its leafs is "Scientists" Clinical experts" "Patients" "Drug developers" "Manufacturers" "Regulators"
  • Prof Katsuto Tamai and Prof Dennis Roop chairing session 3 "Cell therapies – BMT, MSC, fibroblasts clinical trials update"
  • Scientific poster gallery
  • Two researchers in front of their research poster
  • Group of speakers of session 1 ("Protein therapy") on the podium, answering questions from the audience (panel discussion)
  • Conference hall with audience
  • John Dart, COO of DEBRA International, showing a PPT slide with all national member groups (countries) of DEBRA International
  • Inigo Montero and another young man with EB on the podium (Patient Forum report: A patient perspective on research priorities)
  • Prof Leena Bruckner-Tuderman (conference chair) on the speaker's podium
  • Prof Jouni Uitto (conference chair) on the speaker's podium
  • Dr Clare Robinson, DEBRA International research manager, on the speaker's podium
  • Minerva Quijera and Evanina Makow, local organisors of DEBRA Spain, on the speaker's podium
  • Group picture of the DEBRA Spain team (local host)
  • Group picture of all conference participants in the hotel foyer
  • Social evening programme (Sherry and ham tasting): a man pouring sherry into a glas
  • Social evening programme (Sherry and ham tasting): man cutting up "jamon" (traditional Spanish ham)
  • Social evening programme: group picture of traditional Spanish folk dancers
  • Dr Clare Robinson, DEBRA International research manager, with a beautiful flower bouquet

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