DEBINT4.GIF (10584 bytes)

DebRA International Completed  Research Projects

  Completed Research Project

 End Date Researcher
Creation of an EB squamous cell carcinoma tissue bank. 2006 Bruckner-Tuderman
McGrath
Concerted Research Programme for the Development of "ex vivo" Gene Therapy for Recessive Dystrophic EB 2003 Prof Alain
Hovnanian
The DebRA Research Fellow 2003 Prof John McGrath
Ribozyme Gene Therapy for Dowling Meara Epidermolysis Bullosa Simplex

Ref: McLean 8

 2005 Prof Irwin McLean
Ribozyme Gene Therapy for Dominant Forms of Epidermolysis Bullosa 2004 McLean
Developing spliceosome mediated RNA trans-splicing (SMART) for gene therapy in EB. Ref: Bauer 1 04/2004 Bauer
Initiation of cell cultures from squamous cell carcinomas complicating RDEB 10/2003 Bruckner - Tuderman
Mutation Detection and Analysis in EB Simplex 10/2003 Lane
Establishment of an Animal Model for Gene Therapy of Recessive Dystrophic EB 05/2003 Meneguzzi
The Role of Plakophilin 1 in Keratinocyte Cell Biology 08/2002 McGrath
Cytokine-matrix-interactions in the control of scarring: Potential relevance for the clinical management of patients with Dystrophic Epidermolysis Bullosa. 2002 Schor
Towards the Improved Clinical Management of Patients with Epidermolysis Bullosa: Matrix modulation of Stromal Cell Activation and De-activation during Wound Healing 2002 Schor
Assembly of Hemidesmosomes and Identification of Novel Hemidesmosomal Components 2002 Sonnenberg
Correction of Gene Defects in
Epidermolysis Bullosa Simplex using
Chimeric RNA/DNA Oligonucleotides		 2002 Rugg
Establishment of a Registry of Epidermolysis Bullosa and Other Disorders of Keratinization in Northern Ireland 2002 McKenna
Generation of a Novel "switch on and off" Mouse Model for Epidermolysis Bullosa Simplex 2002 Magin
Use of Human Artificial Chromosomes (HAC) to Restore Normal Collagen VII Expression in RDEB Keratinocyte Cell Lines 06/2002 Larin
Gene Therapy Strategies for Skin Fragility 2002 Lane
Ocular Complications in Epidermolysis Bullosa: a Nationwide Database 11/2002 Kerr-Muir
Improved molecular diagnosis of DEB and ex-vivo genetic complementation for RDEB using COL7A1 full length cDNA. 10/2002 Hovnanian
An Inducible Mouse Model for Epidermolysis Bullosa Simplex (EBS): an Explanation for the Absence of Mosaic Forms of EBS and Implications for gene therapy 2002 Roop
Application of Protein Truncation Test to the Diagnosis of Dystrophic and Junctional Epidermolysis Bullosa 1998 Abbs
Analysis of p27BBP (b 4 Binding Protein) Mutations in patients affected by EB 1999 Biffo
Biological consequences of glycine substitution mutations in the COL7A1 gene

2000

Bruckner-
Tuderman
Molecular Analysis of Epidermolysis Bullosa Dystrophica in Italy: Genotype - Phenotype Correlation. 1999 Colombi
Molecular Pathology of Junctional & Dystrophic Forms of Epidermolysis Bullosa, with Genotype Phenotype Correlations. 1998 Eady
The DebRA Research Fellow 2000 Eady
Investigating the role of a 3 - Integrins in Epidermal - Dermal Blister Formation 1999 Hodivala-Dilke
Genetic Correction of COL7A1 Defects for the Treatment of Recessive Dystrophic Epidermolysis Bullosa 1999 Hovnanian
Improved molecular diagnosis of Dystrophic Epidermolysis Bullosa (DEB) and ex vivo genetic complementation for Recessive DEB (RDEB) using COL7A1 full length cDNA 2001 Hovnanian
Ocular Complications in Epidermolysis Bullosa: a Nationwide Database 2002 Kerr-Muir
Direct Automated DNA Sequencer for Analysis of EB Simplex & Related Disorders. 2000 Lane
Understanding the Molecular Basis of Junctional Epidermolysis Bullosa and related Disorders 1999 McGrath
Direct Automated DNA Sequencing to Establish Molecular Pathology in Epidermolysis Bullosa Sufferers 1999 McGrath
Preimplantation Genetic Diagnosis of Epidermolysis Bullosa 1999 McGrath
Gene Therapy for Junctional EB 1999 McGrath
The Role of Plakophilin 1 in Keratinocyte Cell Biology 2002 McGrath
Significance of Mutation Detection in Dystrophic and Junctional E B 2001 McGrath
Establishment of a Genome Screening System Dedicated to EB Research and Identification of the Gene for Laryngo-Onycho-Cutaneous (LO C) Syndrome: a new form of EB 1999 McLean
Ribozyme Gene Therapy for Dominant Forms of Epidermolysis Bullosa 2001 McLean
Construction of Transplantable Skin Grafts using Phenotypically Reverted Junctional EB Keratinocytes 2000 Meneguzzi
Establishment of a Model System for Gene Therapy of Mild Junctional EB 2000 Meneguzzi
The identification of pathogenic mutations in patients with Epidermolysis Bullosa Simplex (EBS) 2001 Rugg
Development of Gene Correction for Generalised Atrophic Benign Epidermolysis Bullosa (GABEB) 1999 Shheffer
Jonkman
Development of DGGE Analysis of the Complete Collagen Type VII Gene for Rapid Molecular Diagnosis of All Forms of Dystrophic E B 2000 Scheffer
Cancer Pathogenesis in EB Patients:  Assessing the Contribution of Activated Stromal Cells 2001 Schor
Role of BP180 & a6B4 in Human Diseases 2001 Sonnenberg

                                                       

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